ODCs

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2 OMIM references -
1 associated gene
50 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 9

1 OMIM reference -
1 associated gene
22 signs/symptoms

EEC syndrome

ADULT syndrome

TP63

(UniProt - OMIM)

TP63

(UniProt - OMIM)


COMMON GENES	TP63

Citations in the biomedical literature:

EEC syndrome		ADULT syndrome
	Synonym(s): - Ectrodactyly - ectodermal dysplasia - cleft lip/palate		Synonym(s): - Acro-dermato-ungual-lacrimal-tooth syndrome - Pigment anomaly - ectrodactyly - hypodontia

	Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease - Rare maxillo-facial surgical disease - Rare otorhinolaryngologic disease - Rare renal disease - Rare skin disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease - Rare odontologic disease - Rare skin disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: normal Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: - Type of inheritance: autosomal dominant

	External references: 2 OMIM references - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: C538052


COMMON SIGNS	- Breast tissue / mammary gland absence / aplasia - Dry / squaly skin / exfoliation - Dysplastic / thick / grooved fingernails - Dysplastic / thick / grooved toenails - Fine hair - Hypoplastic / absent nipples - Oligodactyly / ectrodactyly of toes - Syndactyly of fingers / interdigital palm - Syndactyly of toes

EEC syndrome		ADULT syndrome
	Very frequent - Absent / decreased / thin eyebrows - Anodontia / oligodontia / hypodontia - Autosomal dominant inheritance - Coarse / thick hair - Complete / partial microdontia - Defect / anomaly of lacrimal system - Enamel anomaly - Hyperkeratosis / ainhum / hyperkeratotic skin fissures - Multiple caries - Oligodactyly / ectrodactyly of fingers - Taurodontia - Thick / bushy eyebrows Frequent - Agenesis / hypoplasia / aplasia of kidneys - Chronic uveitis / blepharitis / episcleritis / scleritis / conjonctivitis / keratitis - Cleft lip and palate - Corneal ulceration / perforation - Diffuse / generalised skin hypopigmentation / cutaneous albinism - Megaureter / hydronephrosis / pyeloureteral junction syndrome - Photophobia - Skin hypoplasia / aplasia / atrophy - slow growth of the hair - Urethral anomalies / stenosis / posterior urethral valves / megalocystis Occasional - Capillary hemangioma / nevus / naevus flammeus / port-wine stain - Choanal atresia - Cleft palate without cleft lip / submucosal cleft palate / bifid uvula - Ectropion / entropion / eyelid eversion - External ear anomalies - Hypohidrosis / decreased sweating / thermoregulation disorder / heat intolerance - Hypospadias / epispadias / bent penis - Hypothalamic-hypophyseal axis functional anomalies / hypopituitarism - Intellectual deficit / mental / psychomotor retardation / learning disability - Lymphoma - Mouth dryness / xerostomia - Proximally set thumb - Sensorineural deafness / hearing loss - Short stature / dwarfism / nanism - Structural anomalies of inner ear / cochlea / vestible / semicircular canals - Structural anomalies of middle ear / ossicles / tympanic cavity - Thumb hypoplasia / aplasia / absence - Thymic aplasia / hypoplasia - Vesicorenal / vesicoureteral reflux		Very frequent - Anomalies of eyelids, eyelashes and lacrimal system - Anomalies of teeth and dentition - Chronic skin infection / ulcerations / ulcers / cancrum - Excessive freckling - Nails anomalies - Pigmented naevi / naevus pigmentosus / lentigo - Thin skin Frequent - Alopecia - Hypotrichosis / atrichia / atrichiasis / scalp hairlessness - Tooth shape anomaly Occasional - Broad nose / nasal bridge - Face / facial anomalies - High nasal bridge